Metabolic Factors  NAFLD  內(nèi)容預(yù)覽： 

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Metabolic Factors / NAFLD on the Natural History of Chronic Hepatitis B or C in Asia
Pei-Jer Chen
National Taiwan University & Hospital

HBV or HCV
Hepatic steatosis
Insulin resistance
Metabolic Factors

Flow chart of the REVEAL cohort
23820 cohort members (11973 males and 11847 females), recruited in 1991
4155 HBsAg sero-positive (2445 males and 1710 females)
19665 HBsAg sero-negative
(9528 males and 10137 females--- anti HCV assay

Cross-Section Study: CHB/CHC versus Control in terms of Metabolic Factors
A study of base-line data in the REVEAL cohort

Metabolic factors:
Obesity
Central obesity: waist circumferences >90 cm for men
and >80 cm for women.
Body Mass Index: normal weight BMI< 23 kg/m2
overweight 23 < BMI < 25 kg/m2
obese 25 < BMI < 30 kg/m2
morbid obese BMI > 30 kg/m2
Hypercholesterolemia: total cholesterol > 240
mg/dL
Hypertriglyceridemia: TG > 150 mg/dL
History of DM
History of hypertension

Table . Multivariate-adjusted odds ratios of being HBsAg seropositive in relation to selected metabolic factors

HBV Infection does not Correlates with the Development of NAFL or IR (1)

HBV Infection does not Correlates with the Development of NAFL or IR (2)

Summary
Obesity, history of diabetes :  Prevalence not increase in HBsAg sero-positive subjects
TG>150:      in HBsAg sero-positive cases

Metabolic Factors  NAFLD  ***下載